Stability of Aspirin

Experiment 4: The Stability of Aspirin Introduction Drugs ar produced in various ways and they are presented in galore(postnominal) forms, they get reveal undergo chemical decomposition or chemical abasement in a period of time later on production. This can lead to a substantial lowering of the timeworn of the therapeutic agent in the dosage form.1 T here(predicate)fore, it is important to come up up show up the best storage condition for that special drug, so that the drug can maintain its effect and smell for the semipermanent time, thus maintaining its stableness. That particular length of time is cognise as the shelf-life. Many factors will influence drug constancy such as the pH and temperature. By understanding the kinetics of the subprogram of the breakdown of drug, the amount of drug fragments in a given(p) time can be predicted. The effect of temperature on the constancy of acetylsalicylic irate (aspirin) was being investigated in this try. The equ ation of the reaction of acetylsalicylic hot is: Acetylsalicylic dot Acetic acid + Salicylic acid The application considered here was the stability of aspirin in solution, and how the rate of decomposition wide-ranging with temperature. From the above equation, acetylsalicylic acid would decompose to acetic acid and salicylic acid under moist condition.

To procure the kinetic data on the stability of drug, a turn out known as accelerated stability test was taken. The decomposition of the drug was speeded up during the experiment while retaining the rank rewrite of different formulations.2 Aims UV spectroscopy was used in the experiment to ! obtain a number of kinetic data. Besides gaining serviceable experiences in assaying the equipment, the aims of the experiment were to understand the ways that temperature influenced reaction rate by ascertain the order of reaction with respect to acetylsalicylic acid; finding out the effect of temperature on the rate invariant; and finding out the activation energy via the Arrhenius equation, which described how rate...If you involve to get a full essay, order it on our website: OrderCustomPaper.com

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